Joint Nutra Care

Why is Joint Nutra Care in two parts?   Well for many reasons:  it  gives us a vegetarian option in formula 2, and formula 1 needs to be taken on an empty stomach and formula 2 with food.   Depending on your condition, taking formula 1 and 2 alone can have great results so you can get started on JNC for cheaper.   For example if your condition is primarily chronic inflammation or tendonitis then formula 2 is the most needed.  If you have primarily osteoarthritis then formula 1 is the most needed.  However, for many people taking both formulas would be the best.

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FORMULA 1

Benefits of Formula 1

• Help repair cartilage, tendons, and ligaments, and increase their strength, help control inflammation in the joints and throughout the body, stimulate chondrocytes to produce more cartilage with Collagen type II, Egg Shell Membrane and Hyaluronic Acid.

• Control oxidation damage to joints with olive leaf extract.

• Improve cartilage, tendon and ligament strength with the important mineral sulfur in the form of MSM.

Formula 1 ingredients:

1.   Collagen Type II (KollaGen II-xs™ from Certified Nutraceuticals) http://certifiednutra.com/products-koll collagen type II agen_IIxs.php) 500 mg

Collagen type II sourced from chicken sternum cartilage is the major component of joint cartilage, containing naturally occurring mucopolysaccharides: hyaluronic Acid, chondroitin, and glucosamine.  KollaGen II-xs  is only hydrolyzed down to 20,000 daltons (20 kDa) to preserve the properties of the mucopolysaccharides, whereas most collagen on the market is hydrolyzed down to 1500 daltons (1.5 kDa).
A 30 day clinical trial (using Kollagen II-xs) of 15 middle aged men and women with joint pain, using 1500 mg, showed a 78% reduction in pain and a 62% increase in flexibility.  The study also showed a normalizing of saliva pH (4.7 pre-trial to 7.1 post-trial) levels which is often indicative of a reduction in inflammation throughout the body.  Collagen type II has also been shown to reduce signs of skin aging.  Health Med Journal Volume 10/Number 2/2016

2.   Egg Shell Membrane (KollaGen I.V.X.HEM™) http://certifiednutra.com/products-kollagen_I_V_X.php 500 mg

Hydrolyzed egg membrane contains very powerful compounds including: elastin, collagen, desmosine, isodesmosine and transforming growth factor-β and a complex of glycosaminoglycans such as glucosamine, chondroitin, and hyaluronic acid and other effective compounds. The compounds are proven to be of use for pain management associated with joint disease.  It elevates fibroblast activity stimulating their growth and strengthening the matrix.  A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen.
A Clinical trial with 20 people with joint pain, using 750 mg/day of 50/50 mixture of KollaGen II-xs and KollaGen I.V.X.HEM,  showed a reduction in pain from 10 to 1.5 in 30 days.  Again saliva PH was normalized from 4.7 to 7.5. This trial was performed by Molecular Biology International 3901 Dogwood Ave Sioux Center IA 51250.  Another clinical trial using just Kollagen I.V.X.HEM with 20 people in 30 days showed an average improvement in pain from 8.5 to 1.0.  It also normalized glucose levels in two of the subjects that were diabetic.  http://certifiednutra.com/press-2014-01-23.php

3.   Hyaluronic Acid from rooster comb   http://certifiednutra.com/products-ha95.php  40 mg

Hyaluronic acid is a glycosaminoglycan, a very long chain of disaccharides (sugars) present in all connective tissues that is responsible for retaining moisture. As we age, levels of hyaluronic acid fall, some say by as much as 50 percent.  Taking HA orally increases the body’s own production of HA.   HA from rooster comb is the best form of HA for rapid utilization by the body, and is the form used by MD’s for injections into joints.  Many studies have been done showing the effectiveness of oral HA (50-60 mg/day).   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729158/

4.    Olive leaf extract or Hydroxytyrosol  https://joyofhealth.biz  /product/olea25tm/  40 mg

Hydroxytryrosol found in extra virgin olive oil is the most powerful antioxidant found to date, and believed to be one of the reasons for the health benefits of the mediterranean diet   It  has important benefits to joints by protecting chondrocytes from oxidative stress and stimulating chondrocytes to do there job.
25 adults with early osteoarthritis of the knee were given one tablet of 50 mg/day of olive extract (10 mg HT) or placebo for 4 weeks. A significant diminution in pain was observed in the group after 2 and 4 weeks of HT treatment, pointing to HT as effective treatment to reduce pain in patients with osteoarthritis.   HT also helps lower inflammation biomarkers, and helps with diabetes, high blood pressure and cancer.
Takeda, R.; Koike, T.; Taniguchi, I.; Tanaka, K. Double-blind placebo-controlled trial of hydroxytyrosol of Olea europaea on pain in gonarthrosis. Phytomedicine 2013, 20, 861–864. [Google Scholar] [CrossRef] [PubMed]

5.   MSM Methyl-sulfonyl-methane  1120 mg

MSM is the form of sulfur that is found in plants but is lost with heating or freezing during food preparation.  Sulfur is necessary for the formation of connective tissue and cartilage.  MSM has been widely studied for its use in arthritis and joint inflammation.  MSM has many amazing health benefits such as natural pain killer, antioxidant, and anti-inflammatory.  To get the full story on MSM go to www.msm-info.com.

Formula 2

Benefits of Formula 2

• Naturally lower inflammation biomarkers
• Protect joints and the body from oxidation damage.
• Stimulate chondrocytes to produce more cartilage.
• Improve important hormone levels: DHEA, testosterone and estrogen, and Vitamin D, which in turn helps joints repair.
• Improve bone density with the key minerals Boron , Zinc and Copper.
• Support tendon, ligament and cartilage strength with the important mineral sulfur, in MSM.
• Improve overall health through activation of the SIRT-1 longevity gene and many other mechanisms seen below.
• Protect the telomeres on the end of chromosomes for overall health benefits.

Formula 2 Ingredients:

1.   Olive leaf extract  30 mg and MSM 250 mg are also in formula 1 see above.

2.   Reverse-Vine 100 mg

A type of resveratrol but more powerful.   Research shows that 100 mg of reverse-Vine gives a 50% increase in activation of the SIRT-1 longevity gene which is huge.  The longevity gene helps to keep the whole body younger including our joints.  Resveratrol is also an antioxidant, anti-inflammatory and has anti-cancer properties.    It helps repair mitochondria and slows aging in mice.  In the lab it down regulates production of cartilage degrading enzymes, and also stimulates chondrocytes.

3.   Pomegranite seed extract 300 mg

A powerful anti-inflammatory reducing COX2 by 30% and inhibit IL-1β-induced production of nitric oxide (NO) and PGE2   by 70% in chondrocytes, which cause the degradation of cartilage.  It also has anticancer properties with multiple studies showing that pomegranate extracts inhibit the proliferation of breast cancer cells and even stimulate the programmed cell death of breast cancer cells.   Pomegranate seed oil contains punicic acid, an omega-5 long chain polyunsaturated fatty acid that has been shown to inhibit breast cancer proliferation.  Further research suggests that  pomegranate juice may also slow the growth of prostate cancer, the leading cancer for men in the U.S.  In a study of male subjects with recurrent prostate cancer and rising prostate-specific antigen (PSA) levels, researchers found that taking pomegranate juice extract significantly slowed the rate at which PSA was rising. Other studies have found that certain compounds in pomegranate juice show potent anti-tumorigenic effects and inhibited the growth of prostate cancer cells in the laboratory.  It is also an aphrodisiac because it keeps testosterone from turning into estrogen, it helps lower blood pressure by 15%, and helps remove artherosclerotic plagues by 30%.

4.   Milk Thistle or Silymarin  300 mg

Milk Thistle has been used for centuries to treat liver and spleen problems.  But it is also a powerful anti-inflamatory with studies showing that 300 mg/day worked better than piroxicam or meloxicam both nsaids.  With Silymarin reducing inflammation components by more than 50% in patients with OA, and the piroxicam and meloxicam having minimal to no affect.   It also has anticancer properties.

5.   Bosweillia Serrata 65% extract 300 mg

Boswellia serrata, also known as Indian frankincense, is one of the ancient and most valued herbs in Ayurveda.   Boswellia inhibits the pro-inflammatory enzyme 5-LOX.  Clinical trial:  30 patients received Boswellia Serrata 50% extract 333 mg 3 times a day for 30 days had a reduction in pain of 90% and improvement in ROM of 80%.

6.   Asthaxanthin 60 mg at 5% Asthaxanthin or 3 mg

Astaxanthin has been called the miracle supplement of the 21st century.  It is a powerful antioxidant and 6000 times stronger than Vit C.   But it is also a powerful anti-inflammatory:  2 to 8 mg reduces C reactive protein CRP by 50% and MMP-13 by 75% both very important inflammation markers.   In OA and RA cartilage, MMP-13 production results in the loss of type II collagen, tensile properties, and structural integrity of the affected joint.

7.  Curcumin 100 mg

People in India Refer to Turmeric as ‘Holy Powder’.   A double-blind controlled-trial in which three groups received curcumin (400 mg/day), a placebo, or phenylbutazone (100 mg/day) for five consecutive days after surgery. Treatment with curcumin resulted in reduced inflammation more effectively than phenylbutazone
A Published study has found curcumin to substantially suppresses systemic inflammation markers MMP-3 by 48% to 99%, and MMP-13 by 45% to 97%. Researchers concluded curcumin could be useful for reducing cartilage degradation by MMPs in arthritis.

8.   Boron from Calcium Fructo-Borate  220 mg supplying 5.4 mg boron

FruiteX-B is a form of the mineral boron that is found in food and is highly absorbable.  Boron is a nutrient woefully lacking in American soil , normal intact in USA is 1 to 2 mg.   Low boron levels have been associated with an increase in osteoarthritis (OA) rates as well as rheumatoid arthritis and many other diseases including cancer.   Areas of the world where boron intact is less than 1 mg per day the incidence of OA is 20-70%, areas where it is 3-10 mg the incidence is 0 to 10%.   High Boron intact increases Vitamin D and hormone levels such as DHEA, estrogen and testosterone by 25 to 40%.  Boron along with zinc and copper (as well as calcium) are important elements for increasing bone density and preventing osteoporosis.

9.   Zinc and Copper  16 and 2 mg

Zinc and copper are 2 key minerals needed joint and overall health that are often in low amounts in the diet  So we have added it to formula 2 in amounts that won’t exceed safe limits if you supplement with this in your multi-vitamin.  For more information on minerals needed for joint health go to  Zinc Copper and other Minerals  There is an interesting write up there about silicon and silicon in beer.