Mangosteen Pericarp

• Mangosteen is a tropical plant native to Southeast Asia. The fruits are consumed as food and also used in traditional medicine to treat skin infections, wounds, and diarrhea. Mangosteen juice is marketed as a health drink and the pericarp, or fruit hull, is used in dietary supplements for its antioxidant activity. Preliminary data show that xanthones, bioactive compounds in mangosteen, exhibit antibacterial, antifungal, anti-inflammatory, anti-atherosclerotic , anti-asthmatic, anti-angiogenic, cytotoxic (kills cancer), aromatase-inhibitory, and anticancer properties. ¹
• Clinical trial using 500 mg/day of men and women over age 55 with knee pain showed

an average reduction in knee pain of 52% at the 28 day mark. ²

• The xanthones found in mangosteen are being demonstrated to reduce inflammation by inhibiting the body’s production of the COX-2 enzyme and blocking the process that leads to inflammation. ³
• Alpha-Mangostin protects rat articular chondrocytes against IL-1β-induced inflammation and slows the progression of osteoarthritis in a rat model ⁴

1. https://www.mskcc.org/cancer-care/integrative-medicine/herbs/mangosteen
2. https://www.researchgate.net/publication/265786492_Consumption_of_Mangosteen_Fruit_Pulp_Powder_MX3_provides_beneficial_effect_on_knee_discomfort_not_associated_with_injury_A_double_blind_placebo-controlled_pilot_clinical_study
3. https://www.naturalhomecures.net/mangosteen/science-xanthones/alpha-mangostin-and-gamma-mangostin
4. https://pubmed.ncbi.nlm.nih.gov/28858724/