- It is truly amazing the health benefits of Bromelain and Papain from controlling cancer and improving heart disease to helping with arthritis.1
- These enzymes help break down a protein called fibrin that is deposited in joints by an over active inflammation response and can disrupt the healing process.
- A clinical trial of 77 adults with knee pain, using 200 and 400 mg/day Bromelain showed a reduction in OA symptoms of 41% and 59% respectively after 4 weeks 2.
- In another study 103 patients with osteoarthritis of the knee were divided into two groups to receive 90 mg of bromelain three times a day or 50 mg of diclofenac (a non-steroidal anti-inflammatory drug) twice daily. The two interventions were equally effective at improving each of the measures tested: joint tenderness, pain, range of motion, swelling In addition, patients who used bromelain said they had less pain when at rest, as compared to diclofenac. 3
- In another trial on back pain patients showed a 20% reduction in back pain after 6 weeks using 2 Bromelain and Papain (250 mg total) compared to standard treatment of the NSAID aceclofenac.4
- Many studies have shown that bromelain has a positive effect on arthritis (osteoarthritis and rheumatoid arthritis)5
- A clinical trial using 650 mg (turmeric, devils claw and Bromelain) showed a 44% reduction in symptoms of OA after 60 days. 6, 7
- Bromelain has been used as a food supplement alternative to nonsteroidal anti-inflammatory drugs (NSAIDs). 8
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534447/
- https://pubmed.ncbi.nlm.nih.gov/12587686/
- ncbi.nlm.nih.gov/pubmed/15278753
- Pak J Pharm Sci. 2020 Jan;33(1(Supplementary)):371-378. Efficiency of proteolytic enzymes in treating lumbar spine osteoarthritis (low back pain) patients and its effects on liver and kidney enzymes
- Pavan R., Jain S., Kumar A. Properties and Therapeutic Application of Bromelain: A Review. Biotechnol. Res. Int. 2012;2012:1–6. doi: 10.1155/2012/976203
- Conrozier T., Mathieu P., Bonjean M., Marc J.F., Renevier J.L., Balblanc J.C. A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain. Altern. Ther. Health Med. 2014;20:32–37. https://pubmed.ncbi.nlm.nih.gov/24473984/
- Grover A.K., Samson S.E. Benefits of antioxidant supplements for knee osteoarthritis: Rationale and reality. Nutr. J. 2015;15:1. doi: 10.1186/s12937-015-0115-z. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700773/
- Brien S., Lewith G., Walker A., Hicks S.M., Middleton D. Bromelain as a treatment for osteoarthritis: A review of clinical studies. Evid. Based Complement. Altern. Med. 2004;1:251–257. doi: 10.1093/ecam/neh035.