Bromelain & Papain

  • It is truly amazing the health benefits of Bromelain and Papain from controlling cancer and improving heart disease to helping with arthritis.1
  • These enzymes help break down a protein called fibrin that is deposited in joints by an over active inflammation response and can disrupt the healing process.
  • A clinical trial of 77 adults with knee pain, using 200 and 400 mg/day Bromelain showed a reduction in OA symptoms of 41% and 59% respectively after 4 weeks 2.
  • In another study 103 patients with osteoarthritis of the knee were divided into two groups to receive 90 mg of bromelain three times a day or 50 mg of diclofenac (a non-steroidal anti-inflammatory drug) twice daily. The two interventions were equally effective at improving each of the measures tested: joint tenderness, pain, range of motion, swelling In addition, patients who used bromelain said they had less pain when at rest, as compared to diclofenac. 3
  • In another trial on back pain patients showed a 20% reduction in back pain after 6 weeks using 2 Bromelain and Papain (250 mg total) compared to standard treatment of the NSAID aceclofenac.4
  • Many studies have shown that bromelain has a positive effect on arthritis (osteoarthritis and rheumatoid arthritis)5
  • A clinical trial using 650 mg (turmeric, devils claw and Bromelain) showed a 44% reduction in symptoms of OA after 60 days. 6, 7
  • Bromelain has been used as a food supplement alternative to nonsteroidal anti-inflammatory drugs (NSAIDs). 8

 

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534447/
  2. https://pubmed.ncbi.nlm.nih.gov/12587686/
  3. ncbi.nlm.nih.gov/pubmed/15278753
  4. Pak J Pharm Sci. 2020 Jan;33(1(Supplementary)):371-378. Efficiency of proteolytic enzymes in treating lumbar spine osteoarthritis (low back pain) patients and its effects on liver and kidney enzymes
  5. Pavan R., Jain S., Kumar A. Properties and Therapeutic Application of Bromelain: A Review. Biotechnol. Res. Int. 2012;2012:1–6. doi: 10.1155/2012/976203
  6. Conrozier T., Mathieu P., Bonjean M., Marc J.F., Renevier J.L., Balblanc J.C. A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain. Altern. Ther. Health Med. 2014;20:32–37. https://pubmed.ncbi.nlm.nih.gov/24473984/
  7. Grover A.K., Samson S.E. Benefits of antioxidant supplements for knee osteoarthritis: Rationale and reality. Nutr. J. 2015;15:1. doi: 10.1186/s12937-015-0115-z. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700773/
  8. Brien S., Lewith G., Walker A., Hicks S.M., Middleton D. Bromelain as a treatment for osteoarthritis: A review of clinical studies. Evid. Based Complement. Altern. Med. 2004;1:251–257. doi: 10.1093/ecam/neh035.

 

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